Abstract:Objective To explore the relations between alexithymia, loneliness, resilience, and non-suicidal self-injury(NSSI)behaviors in adolescents with depression, and investigate the mechanism. Methods The functional assessment of self-mutilation(FASM), Toronto alexithymia scale(TAS), UCLA loneliness scale, and the Connor-Davidson resilience scale(CD-RS-10)were used to investigate 326 adolescents with depression. The relations among the variables and possible moderated mediating relationships were analyzed. Results Alexithymia and loneliness were significantly positively correlated with the NSSI behaviors, while resilience was significantly negatively associated with NSSI behaviors. Compared with non-NSSI group, total score of alexithymia, difficulties in emotion recognition and description, scores of extraversion thinking dimension, and total score of loneliness in the NSSI group were significantly higher, while the score of resilience was significantly lower(P<0.01). Alexithymia positively predicted the development of NSSI, while resilience negatively predicted the development of NSSI. Alexithymia influenced NSSI through the mediating role of resilience, and loneliness moderated the first half of this mediating model. Conclusion Loneliness, resilience, and alexithymia of adolescents with depression are significantly correlated with NSSI behaviors. Alexithymia is a risk factor for the development of NSSI, while the resilience is a protective factor in reducing NSSI behaviors. Resilience plays a mediating role in the relationship between alexithymia and NSSI behavior, with loneliness playing a moderating role.