Objective  To evaluate the clinic effect of the night-wearing orthokeratology (OK) lens in teenagers with low and moderate refractive errors. Methods  A total of 90 adolescent myopia patients [176 eyes，aged (10.5±2.2) years] were enrolled in this retrospective study. Uncorrected visual acurity (UCVA) was measured at baseline and 1 week，1，3，6，12 and 18 months after wearing OK lens. Refractive error (spherical equivalent)，central corneal thickness，corneal topography eccentricity (E-value)，axial length，keratometry 1 (K1)，keratometry 2 (K2)，average keratometry，and intraocular pressure were assessed at baseline and 18 months after wearing OK lens. The contributions of all independent variables on axial length change and refractive error change were assessed using univariable regression analysis. According to the refractive baseline，the subjects were divided into two groups: low myopia group (-0.5~-3.0 D，46 cases with 88 eyes) and moderate myopia group (-3.25~-5.75D，44 cases with 88 eyes). The axial length changes and refractive error changes were evaluated. According to the age，the subjects were divided into three groups: group A (≤9 years)，group B (9 years<age<12 years)，and group C (≥12 years). The axial length and refractive error changes were evaluated. The subjects in the low and moderate myopia groups were divided into three subgroups according to the age，and the changes of axial length and refractive error were evaluated. Results  The refractive baseline was (-2.93±1.09) D and axial length was (24.73±0.78) mm. UCVA was significantly increased after wearing OK lens at each time point of the follow-up (P<0.01). There were significant differences in the axial length，refractive error，K1，K2 and average K between before and 18 months after wearing OK lens (P=0.0001). Univariate analysis showed that the increases of the axial length and refractive error were significantly related to the onset age of OK lens wearing，initial corneal E value，initial axial length，and baseline refractive error. The increases of refractive error and axial length in lower myopia group were significantly larger than those in the moderate myopia group (P<0.01). There was significant difference in the increase of refractive error (group A＞group B=group C) and the elongation of axial length (group A＞group B＞group C). The refractive degrer and axial length were most quickly increased in the teenagers aged ≤9 years in both low and moderate myopia groups. Conclusion  OK lens is effective to correct  myopia to a certain degree. The increases of the axial length and refractive degree in the lower baseline refractive error and lower age subjects develop faster.