The response inhibition in adolescents with anxiety disorder:an ERP study on Go/NoGo N2 and P3
ZHANG Jinsong,WANG Xin,CHENG Wenhong,LIU Yi
1. Department of Child and Adolescent Health,Department of Medical Psychology,Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine,MOE-Shanghai Key Laboratory of Children’s Environmental Health,Shanghai 200092,China;2. Shanghai Mental Health Center,Shanghai Jiaotong University School of Medicine,Shanghai 200030,China
Abstract:Objective To investigate the mechanisms involved in the regulation of stimulus response in adolescents aged 13 to 16 years with anxiety disorder(ANX)using Go/NoGo tasks. Methods The subjects in this study included ANX adolescents and normal children as control. Event-related potentials(ERP),N2 and P3 were measured. Results The N2 latencies for ANX were longer than for normal children in Go and NoGo tasks[F(1,26)= 13.26,P < 0.001]. However,no N2 amplitude difference was found between both groups. P3 in ANX adolescents was smaller than in the control group,indicating a deficiency in stimulus evaluation and decision making in ANX,especially at the frontal-central and central areas. Additionally,the severity of anxiety measured by SCARD was correlated with the P3 amplitude. The more severe the anxiety,the smaller the P3 amplitude. Conclusion Except for the longer time to respond,ANX adolescents have no significant deficit in conflict monitoring and response inhibition. In contrast,a significant deficiency is found for the processing of evaluation and decision-making. In addition,P3 seems to be more sensitive than N2 to anxiety.
张劲松;王新;程文红;刘漪. 焦虑障碍青少年的反应抑制性的探讨[J]. , 2013, 1(2): 95-105.
ZHANG Jinsong;WANG Xin;CHENG Wenhong;LIU Yi. The response inhibition in adolescents with anxiety disorder:an ERP study on Go/NoGo N2 and P3. , 2013, 1(2): 95-105.