1. Liuzhou Maternity and Child Healthcare Hospital, Maternity Hospital and Children's Hospital Affiliated to Guangxi University of Science and Technology, Liuzhou 545001, Guangxi Zhuang Autonomous Region, China; 2. Key Laboratory of Developmental Disorders in Children in Liuzhou, Liuzhou 545616, Guangxi Zhuang Autonomous Region, China
Abstract：Objective To investigate the correlation between integrated visual and auditory continuous performance test (IVA-CPT) and event-related potential P300 in children with nocturnal enuresis, and explore its significance in diagnosis. Methods A total of 48 children with enuresis were enrolled as enuresis group, and 57 normal children were enrolled as control group. The visual Oddball paradigm was applied, P300 was measured, and the IVA-CPT was assessed in all patients and controls. Results In the enuresis group, full scale attention/scale quotient, visual attention/control quotient, and auditory attention/control quotient were significantly lower than those of the control group (P<0.01). Children with enuresis showed significantly longer latency and lower amplitude of P300 than normal children (P<0.01), except for P4 amplitude (P>0.05). In children with enuresis, the visual attention/control quotient was positively correlated with P300 (P＜0.05 or P＜0.01), except for P4 amplitude, and negatively correlated with the latency of P300 (P＜0.01). Conclusion Children with nocturnal enuresis may have impaired attention function and impairment of inhibition control, especially in visual cognitive impairment and attention control.
