Objective  To compare the therapeutic effects of two different treatment schemes on children with tic disorders at school age. Methods  A total of 119 children with tic disorders admitted to Huizhou Women and Children's Hospital from November 2017 to August 2018 were selected and divided into control group and observation group by random number table method. Fifty-nine children in the control group were treated with routine intervention (drug + psychological and behavioral intervention). Sixty children in the observation group were treated with biofeedback therapy on the basis of routine treatment. The Yale global tic severity scale (YGTSS) was used to evaluate the symptoms of children before and after treatment. Results  Before treatment，there was no significant difference in motor tic score，vocal tic score，and YGTSS total score between the two groups (P>0.05). After treatment，the motor tic score，vocal tic score，and YGTSS total score in the observation group were significantly lower than those in the control group (P<0.05). After treatment，motor tic score，vocal tic score，and YGTSS total score in the two groups were significantly lower than those before treatment (P<0.05). Conclusion  Biofeedback combined with drug，psychological and behavioral interventions can effectively improve the clinical symptoms of tic disorders in children and increase the clinical therapeutic effect，which is worthy of further promotion in clinic.