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| Advances on epigenetic regulation of oxytocin receptor gene in autism spectrum disorder |
| PAN Lizhu, WANG Yu |
| Department of Children Health Care, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai 200062, China |
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Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disease mainly characterized by social communication disorders, repetitive behaviors, and restricted interests. Although the causes of the disease are very complex and have not yet been identified, most of them are believed to be related to genetic and external environmental factors. In recent years, great progress has been made in the role of oxytocin in ASD, especially the epigenetic effect of the oxytocin receptor gene (OXTR) on ASD. This review will summarize the transcriptional control of OXTR promoter methylation in ASD, the role of OXTR methylation in behavioral phenotype, and the effect of early adverse experiences on the oxytocin system, in order to raise the awareness of the association between the OXTR methylation and ASD.
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ZHENG Rong, YANG Lei, LIU Feng, CHEN Yiqing, HE Yanglu,XU Yaqin, XIE Yachun, ZHANG Min, TONG Meiling, CHI Xia. Study on effect of TPEI model on promoting joint attention of children with autism spectrum disorder[J]. JOURNAL OF BIO-EDUCATION, 2020, 8(3): 171-. |
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