Objective To clarify the clinical efficacy and safety of Qufeng Zhidong recipe combined with risperidone in thetreatment of tic disorder（TD）. Methods A total of 300 children with moderate and severe TD were randomly divided into traditional Chinese medicine group（Qufeng Zhidong recipe）, integrated medicine group（Qufeng Zhidong recipe and risperidone）, and westernmedicine group（risperidone）. The patients were treated for 24 weeks, and were followed up at 2, 4, 8, 12, and 24 weeks after treatment. The total effective rates were scored by using Yale global tic severity scale（YGTSS）and traditional Chinese medicine syndrome scale, and side effects were evaluated at each follow-up time. Results After 24 weeks of treatment, the total effective rates of YGTSS were 91.0 % in the traditional Chinese medicine group, 94.2 % in the integrated medicine group, and 84.4 % in the western medicine group, respectively. There were significant differences between integrated medicine group and western medicine group（P<0.05）. After the 24 weeks’ follow-up, the incidence rates of side effects were 4.50 % in the Chinese medicine group, 0 in the integrated medicinegroup, and 7.78 % in the western medicine group, respectively. There were significant differences among the three groups（P<0.05）. Conclusion The integrated Qufend Zhidong recipe and risperidone treatment has a good curative effect on TD with low side effects.