Objective To analyze recent impact of COVID-19 pandemic home quarantine on infant neuropsychiatric development during the perinatal period. Methods Infants aged 2 months born from October 2021 to January 2022 were selected as the control group（n=177）, and infants aged 2 months born from March to July 2022 were selected as the experiment group（n=119）. The infants in the experiment group experienced the COVID-19 pandemic home quarantine. The neuropsychiatric development of the infants the of two groups at the age of 2 months was compared by using the age and stage questionnaires from five functional areas, including communication, gross motor, fine motor, solving problem, and person-society. Results The incidence rates of neuropsychological development retardation in the experiment group and the control group were 7.56% and 6.78%, with no significant difference（P>0.05）. The scores of communication and female infants’ gross motor in the experiment group were significantly lower than those of the control group（P<0.05）. There were no significant differences among other functional areas’ scores and the total score of infants in both groups （P>0.05）. Conclusion The COVID-19 pandemic home quarantine during the perinatal period has certain negative impact on the communication and female infants’ gross motor skills. Positive intervention measures should be given.