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| Relationship between serum vitamin A and E levels and immune function in children with repeated respiratory tract infection |
| WANG Dingcheng1, ZHANG Hua2 |
1. Department of Neonatology, Huangshi Maternal and Child Health Hospital, E-dong Healthcare Group, Huangshi 435000, Hubei Province, China；
2. Department of Pediatrics, the First Hospital of Tianmen, Tianmen 431700, Hubei Province, China |
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Abstract Objective To investigate the relationship between serum vitamin A and E levels and immune function in children with repeated respiratory tract infection. Methods Tow hundred and forty children with repeated respiratory tract infection recruited from January 2017 to January 2019 were enrolled as case group, and 250 normal children in the same period were recruited as control group. Serum levels of vitamin A and E were detected by high performance liquid chromatography. IgA, IgM and IgG levels were detected by single radial immunodiffusion. The proportions of CD4 ＋ T cells, CD8 ＋ T cells, and CD4 ＋/CD8＋ in the peripheral blood were detected by flow cytometry. Then, the data were compared and the correlation was analyzed between groups. Results Compared with the control group, serum levels of vitamin A and E in the case group were significantly lower (P<0.05), and vitamin A and E deficiencies were significantly higher (P<0.05). Serum levels of IgA, IgM, and IgG, and the proportion of CD4＋T cells, CD8＋T cells, and CD4＋/CD8＋ in the case group were significantly lower than those in the control group (P<0.05). In the case group, there was significantly positive correlation among vitamin A and E and IgA, IgM, IgG, and CD4＋/CD8＋ (P<0.05). Conclusion Vitamin A and E levels in children with repeated respiratory tract infection decrease and are closely related to reduction of immune function.
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