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| Effects of dietary vitamin A intake in late pregnancy on the neonatal vitamin A level and related factors |
| LIU Huan1, MIAO Jingkun2, CHEN Jie1, LI Tingyu1 |
| 1. Children’s Nutrition Research Center, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Children Hospital of Chongqing Medical University, Chongqing 400014, China; 2. Center for Clinical Molecular Medicine, Children Hospital of Chongqing Medical University, Chongqing 400014, China |
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Abstract Objective To explore the effects of dietary vitamin A (VA) intake in late pregnancy on VA level in neonates. Methods According to the inclusion criteria, the neonates born from October to November 2016 at the Second Affiliated Hospital of Chongqing Medical University and their mothers were included, and umbilical cord blood and related case data were collected. The dietary status of pregnant women at the late stage of pregnancy was investigated by food frequency method, the blood retinol levels were measured by high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method and t test or variance analysis were used to analyze the effects. Results Totally 98 mothers and their neonates were included. The excess intake of VA in the mother’s late pregnancy reached 12.24%, with a sufficient rate of 75.51% and a deficient rate of 12.24%.And still, there was a deficient rate of 8.11% among pregnant mothers who took VA supplements. The neonatal umbilical cord blood retinol levels of group in which pregnant mothers took sufficient VA in late pregnancy were obviously higher than that of group in which pregnant mothers took insufficient VA (P=0.000), and the levels of retinol increased with the increase of the intake of red-yellow fruits and liver (P=0.000, 0.010). However, there was no correlation between the neonatal VA level and the intake of fish, shrimp, shell, eggs, milk, dark vegetables, and VA supplements (all P>0.05). The birth weight and head circumference of group in which neonatal retinol levels ≥0.70 μmol/L were significantly higher than that of retinol levels <0.70 μmol/L (P=0.000, 0.040). Pearson correlation analysis showed that there was a significant positive correlation between retinol level and body weight (r=0.245, P=0.245). Conclusion There are still some pregnant mothers who took insufficient and excessive VA in late pregnancy. The neonatal VA level is affected by the diet of mothers in late pregnancy. The birth weight and head circumference of the newborn are related to the VA level. It is necessary to strengthen nutrition guidance during pregnancy to promote early development of children.
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