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| Research advances of gangliosides in neural development |
| CHEN Fei1,2, WU Meiqin1, LIU Jianwen2, YAN Chonghuai1 |
| 1. MOE-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China;2. State Key Laboratory of Bioreactor Engineering and Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China |
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Abstract Gangliosides(GA), containing salivated glycosphingolipids(GSLs), abundant in the nervous system, are major molecular determinants on the surfaces of nerve cells. It is not only involved in the development of the nervous system and higher nervous activities, such as learning and memory, but also highly responsible for some diseases caused by bacteria, viruses, autoimmunity and other factors. Combined with recent years of researches, this paper reviews the changes in ganglioside expression during neural development and the roles in maintaining normal life activities.
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