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| Effect of prepregnancy risk factors on miscarriage: a prospective study |
| HUO Xiaona1, YANG Yulin2, HUANG Hong1, ZHANG Jun1 |
| 1.MOE-Shanghai Key Laboratory of Children’s Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; 2.Department of Maternal and Child Health Care, Shanghai Municipal Health and Family Planning Commission, Shanghai 200125, China |
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Abstract Objective To probe the relation of female and male prepregnancy risk factors to miscarriage. Methods We followed up 6 319 couples who had a prepregnancy health examination in 2012 in 8 districts in Shanghai. A multivariable Logistic regression model was used to examine the association between prepregnancy risk factors and miscarriage. Results In women, hepatitis B surface antibody negative ［adjusted odds ratio (aOR) 1.9，95% confidence interval (CI) 1.2-3.3］, history of adverse pregnancy outcomes (aOR 2.5, 95% CI 1.7-3.7）, history of spontaneous abortion (aOR 2.7, 95% CI 1.8-4.0), family history of diabetes (aOR 1.6, 95% CI 1.1-2.5), and 3rd degree leucorrhea cleanliness (aOR 1.6，95% CI 1.0-2.7) increased the risk of miscarriage. In men, hepatitis B surface antibody negative (aOR 2.2，95% CI 1.3-3.9), exposure to heavy metals (aOR 3.3，95% CI 1.1-9.7), and interpersonal tension (aOR 2.3，95% CI 1.1-4.5) increased the risk of miscarriage of their wives. Conclusion Couples’ prepregnancy diseases history, contact with harmful substances and other prepregnancy risk factors increase the risk of spontaneous abortion.
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