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| Analysis of clinical features of infectious mononucleosis with different age children |
| WANG Xiaopeng1, JIAO Yangyang1,2, CHEN Ling1, WU Liangxia1, ZHANG Jianhua1 |
1. Department of Pediatrics，Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China; 2. Medical Department, Children's Hospital, Shanghai Jiao Tong University, Shanghai 200062, China |
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Abstract Objective To investigate clinical characteristics of infectious mononucleosis (IM) in children and their relation with the onset ages. Methods From January 2009 to December 2013, 268 cases of IM children by age stages were divided into 4 groups: baby group (≤1 year old), childrens group (≤3 years old), preschool group (≤6 years old), and school age group (>6 years old), and were retrospectively analyzed. Results The onset peak was for preschool, and early childhood also accounted for considerable proportion. Fever, lymphnoditis, tonsil effusion, and eyelid edema were found mainly in the older children, and skin rashes were found mainly in younger children with statistical significances (P＜0.05). Hepatomegaly rate of children's group was lower than those of preschool and baby groups, and the difference was statistically significant (P＜0.05). There were no statistical significances in splenomegaly, thrombocytopenia, and liver function damage rates among all age groups (P＞0.05). Anemia and myocardial damage occurred mainly in younger children, and the differences were statistically significant (P＜0.05). Abnormal lymphocyte ratio increased with the increase of age. Except baby group, along with the age increasing, CD4+ T cells decreased and CD8+ T cells increased in other groups. Conclusion The clinical features of childhood IM are associated with the age, which needs to be taken into consideration in order to improve the diagnosis of IM.
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