Abstract：Metaphor is pivotal for the construction of a complex theory. From the perspective of allostery of enzyme，learning is ultimately seen as a change occurring on“active site”of learner’s conceptions. Teachers and mediators can not directly operate the learner’s active site， but who can act on“allosteric site”of learner’s conception system via manipulating the environment that learners interact with so as to trigger some“looseness”or“distortion”（or “deconstruction”）of the conception system and thereby result in a key change（generating new structure and/or new meaning） on the active site. Such a“deconstruction-construction”is a parallel process causing a fundamental learning rather than merely a cognitive process. Using the allosteric learning model，Andre Giordan organically made complex learning elements（biological，psychological，cultural，emotional，epistemological，etc.）integrated，in particular，incorporated subject’s motivation and epistemology into the mechanism on the process of learning. This model provides a strong explanation for daily learning phenomenon.