Abstract:The primary purpose of neurodevelopmental assessment is to identify delayed or abnormal development at an early stage, and provide diagnostic developmental assessment and possible etiological diagnosis for children who have not been passed the screening, so as to help children achieve the maximum potential, give a prompt treatment or intervention, especially of hearing and visual impairment, and provide care and management for children in special needs as early as possible. To understand the concepts of the general rules for development, developmental milestone (skill domains: gross motor, fine motor and vision, language and hearing, social adaptability; median age and limit age), developmental stream, developmental monitoring and screening, and developmental variation, is the basis of neurodevelopmental assessment. Neurodevelopmental assessment starts in the gain of comprehensive history, including birth history, medical history, developmental history, behavior history, education history, social history, and family history. Comprehensive physical examination includes growth parameters assessment, general physical examination, and neurological evaluation. The observation and elicitation of relevant development skills as well as behaviors of the assessed play a challenging part in the process of assessment. Diagnostic interpretation of abnormal development is based on the principle of delay, deviation, and disassociation. Neurodevelopmental assessment should yield a diagnostic summary, an etiological hypothesis, and an early referral and interventional strategies.