Abstract：Autism spectrum disorder (ASD) is a neurodevelopmental disease mainly characterized by social communication disorders, repetitive behaviors, and restricted interests. Although the causes of the disease are very complex and have not yet been identified, most of them are believed to be related to genetic and external environmental factors. In recent years, great progress has been made in the role of oxytocin in ASD, especially the epigenetic effect of the oxytocin receptor gene (OXTR) on ASD. This review will summarize the transcriptional control of OXTR promoter methylation in ASD, the role of OXTR methylation in behavioral phenotype, and the effect of early adverse experiences on the oxytocin system, in order to raise the awareness of the association between the OXTR methylation and ASD.
潘丽珠，王 瑜. 催产素受体基因在孤独症谱系障碍中的表观遗传调控研究进展[J]. 教育生物学杂志, 2020, 8(3): 155-.
PAN Lizhu, WANG Yu. Advances on epigenetic regulation of oxytocin receptor gene in autism spectrum disorder. JOURNAL OF BIO-EDUCATION, 2020, 8(3): 155-.
