Relationship between gut microbiota and severity of symptoms in children with autism spectrum disorder
MA Bingjie1, LIANG Jingjing1, JING Jin2
1. Department of Children Healthcare, Guangzhou Women and Children's Medical Center Affiliated to Guangzhou Medical University, Guangzhou 510623, Guangdong Province, China; 2. Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China
Objective To investigate the relationship between gut microbiota and severity of symptoms in children with autism spectrum disorder(ASD). Methods Between April and July 2017, 45 children with ASD were enrolled in the Research Center for Psycho-Behavioral Development of Children and Adolescents at Sun Yat-sen University in Guangzhou, China. The childhood autism rating scale(CARS) and the social communication questionnaire(SCQ) were used to assess the severity of ASD symptoms. Stool specimens were collected from participants. The fecal microbial DNA was extracted from feces. We characterized the composition of the fecal microbiota using bacterial 16S rRNA gene sequencing. Results There were no significant diversity and structure differences in gut
microbiota between mild-moderate ASD and severe ASD groups. However, the severe ASD group had a smaller number of operational taxonomic units, the rank abundance curve was steeper and the horizontal span was smaller. In addition, the relative abundance of Clostridium clostridiiforme was positively correlated with the restricted and repetitive behavior subscale score(r=0.391, P=0.008). Conclusion Gut microbiota was similar in different severity ASD groups. However, the gut microbiota in severe ASD group trended to be less diverse and more uneven.
马冰洁,梁晶晶,静 进. 孤独症谱系障碍儿童肠道菌群与症状严重程度的关系研究[J]. 教育生物学杂志, 2020, 8(1): 30-.
MA Bingjie, LIANG Jingjing, JING Jin. Relationship between gut microbiota and severity of symptoms in children with autism spectrum disorder. JOURNAL OF BIO-EDUCATION, 2020, 8(1): 30-.