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| Study on expression of DRD5 mRNA in peripheral blood lymphocytes of children with tic disorder and intervention effect of Qufeng Zhidong Decoction on it |
| JIANG Keyu1, MAO Hongliu2, WU Min1, GAO Ge3, ZHANG Xin1 |
| 1. Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; 2.Dachang Hospital of Baoshan District, Shanghai 200436, China; 3. Jinan Central Hospital, Jinan 250013, Shandong Province, China |
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Abstract Objective To detect the expression of DRD5 mRNA in peripheral blood lymphocytes of children with tic disorder, and observe the effect of the traditional Chinese medicine Qufeng Zhidong Decoction on the expression of DRD5 mRNA. Methods A total of 100 children with tic disorder were selected as the research objects (the tic disorder group), and 50 healthy children of the corresponding age were collected as controls (normal control group). Real-time PCR method was used to detect the expression levels of DRD5 mRNA in peripheral blood lymphocytes. The expression of DRD5 mRNA of moderate and severe patients in the tic disorder group were detected before and after the treatment of Qufeng Zhidong Decoction. Results The enrolled children were divided into preschool (<7 years old) and school-age (≥7 years old) for analysis according to their age. The relative expressions of DRD5 mRNA in peripheral blood lymphocytes in the preschool and school-age tic disorder groups were significantly higher than those of the normal control group of the corresponding age (P<0.05). After treatment with Qufeng Zhidong Decoction, the relative expressions of DRD5 mRNA in the preschool, school-age moderate tic disorder group and school-age severe tic disorder group were significantly lower than those before treatment (P<0.05). Conclusion The occurrence and development of tic disorder may be related to the high expression of DRD5 mRNA in peripheral blood lymphocytes. DRD5 can be used as the target of Qufeng Zhidong Decoction to treat tic disorder.
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