Objective　To explore the effects of Internet medical treatment on children's asthma based on pediatric medical alliance. Methods　A total of 120 asthmatic children aged 4-11 years received standard treatment. Through the Internet medical “asthma worry free” APP, the parents of children with asthma were surveyed before enrollment and followed up after enrollment. According to the asthma questionnaire filled in by parents every month, the compliance of children's asthma treatment, asthma control, days of children's absence from school and  parents' absence from work, and medical expenses were compared before enrollment, 3, 6, 9, and 12 months after standard treatment. Results　After 3, 6, 9, and 12 months of asthma treatment, the compliance and control rate of asthma in asthmatic children increased significantly (P<0.01). The number of days of children's absence from school and parents' absence from work, and medical expenses decreased significantly (P<0.01). Conclusion　Standard treatment and management of asthmatic children by Internet medical treatment under pediatric medical alliance can improve the compliance and control rate of asthma, and reduce days of children's absence from school and parents' absence from work, cost of asthma treatment, and burden of family and social economy. It is worthy of popularization and application in clinical medicine.