Objective   To explore the characteristics of adaptive behavior of children with high-function autism spectrum disorder(HFASD) and its influencing factors. Methods   A total of 70 children with HFASD(aged 6-12 yeas) from the Research Center for Psycho-behavioral Development of Children and Adolescents of Sun Yat-sen University from April to July 2017 were recruited. The adaptive behavior, intelligence level, severity of ASD symptoms, executive function, anxiety and intervention therapy were assessed to determine characteristics and influencing factors of adaptive behavior in HFASD children. Results   It revealed that 25.7% HFASD children had a low level of adaptive behavior and 34.3%  a critical level. Only 40% children had adaptive behavior of medium level or above. The difference in the grade distribution between adaptive behavior and intelligence level was statistically significant(P< 0.05). Logistic regression analysis showed that high level of full scale intelligence quotient(FSIQ) was a protective factor for adaptive behavior(OR=1.21, 95%CI: 1.05-1.39), while poor behavioral regulation ability(OR=0.86, 95% CI: 0.74-1.00), lack of social motivation(OR=0.79, 95% CI: 0.57-1.00) and social phobia symptoms(OR=0.01, 95% CI: 0.00-0.33) were risk factors for poor adaptive behavior. Multiple linear regression analysis was carried out, and FSIQ-GAC（full scale intelligence quotient-general adaptive composite）discrepancy scores were taken as dependent variables. It showed that intervention training(β=0.27, P=0.02), especially structured education(β=0.25, P=0.02), could reduce the FSIQ-GAC discrepancy scores and severely damaged social perception(β=0.29, P=0.01) and presence of social phobia(β=0.23, P=0.03) would exacerbate the discrepancy scores. Conclusion The study reveals that adaptive behavior of HFASD children does not match their intelligence level perfectly, and the executive function, severity of symptoms and anxiety symptoms may affect the adaptive behavior.