Peri-operative vitamin D status and its association with postoperative clinical outcome in children with tetralogy of Fallot
YE Xiuxia1, JIANG Chuan1, HONG Haifa1, SUN Jianhua1, BU Jun1, HUANG Hong2, BEI Fei1
1. Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China;2. Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
Objective To detect the peri-operative status of vitamin D and its association with postoperative clinical outcomes in children with tetralogy of Fallot (TOF). Methods Twenty-one children with TOF were randomly enrolled. Blood samples were collected at five time points, including preoperative, immediately after surgery, 24, 48, and 72 hours after surgery. The blood 25-hydroxyvitamin D [25(OH)D] concentration was measured by liquid chromatography/mass spectrometry (LC/MS). Results The median age of the children was 0.66 years. The baseline 25(OH)D was (25.1±9.2) ng/mL(1 ng/mL=0.40 nmoL/L). Vitamin D deficiency rate was 19% before operation, and 81% immediately after surgery. There were significant differences of 25(OH)D concentrations at the five time points (P<0.01). However, no significant difference was showed after control of the cardiopulmonary bypass time (P>0.05). No significant difference was found among 25(OH)D level and the length of hospital stay, cardiac intensive care unit (CICU) stay, and mortality (P>0.05). Area under curve of 25(OH)D concentration was computed. There was no significant difference among the area and the length of hospital, CICU stay, and hospitalization cost (P>0.05). Conclusion Vitamin D deficiency is common in children with TOF. Cardiopulmonary bypass significantly affects the level of 25(OH)D after surgery. Vitamin D deficiency may increase the demand for treatment of advanced antibiotics and vasoactive agents.
叶秀霞,姜 川,洪海筏,孙建华,步 军,黄 红,贝 斐. 法洛四联症患儿围手术期维生素D水平与临床结局的关系[J]. 教育生物学杂志, 2020, 8(2): 106-.
YE Xiuxia, JIANG Chuan, HONG Haifa, SUN Jianhua, BU Jun, HUANG Hong, BEI Fei. Peri-operative vitamin D status and its association with postoperative clinical outcome in children with tetralogy of Fallot. JOURNAL OF BIO-EDUCATION, 2020, 8(2): 106-.