Objective To evaluate the efficacy of Qufeng Zhidong Decoction with drugs for relieving the depressed liver, invigorating spleen, and nourishing Yin in the treatment of tic disorder which has a master syndrome and three accompanying syndromes, in order to discuss the correlation of decoction-syndrome-effect. Methods Patients were randomly divided into treatment group (65 cases) and the corresponding treatment group (66 cases). The patients in the treatment group were divided into syndromes of regulating lung and liver with relieving the depressed liver, invigorating spleen and nourishing Yin. The patients in the corresponding treatment group were treated according to the core syndrome by regulating the function of the liver and the lung. The Chinese medicine symptoms, signs, and curative effect were evaluated in the tow groups in 4, 8, 12, and 24 weeks. Results The total effective rates of the treatment group and the corresponding treatment group were 98% and 90%, respectively, and the difference was not statistically significant (P>0.05). Conclusion Qufeng Zhidong Decoction can significantly improve the symptoms and signs of tic disorder and has no toxic side effect. The total effective rate of the treatment group is slightly higher than the corresponding treatment group, but no significant differences were observed.