Effect of prepregnancy risk factors on miscarriage: a prospective study
HUO Xiaona1, YANG Yulin2, HUANG Hong1, ZHANG Jun1
1.MOE-Shanghai Key Laboratory of Children’s Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; 2.Department of Maternal and Child Health Care, Shanghai Municipal Health and Family Planning Commission, Shanghai 200125, China
Abstract：Objective To probe the relation of female and male prepregnancy risk factors to miscarriage. Methods We followed up 6 319 couples who had a prepregnancy health examination in 2012 in 8 districts in Shanghai. A multivariable Logistic regression model was used to examine the association between prepregnancy risk factors and miscarriage. Results In women, hepatitis B surface antibody negative ［adjusted odds ratio (aOR) 1.9，95% confidence interval (CI) 1.2-3.3］, history of adverse pregnancy outcomes (aOR 2.5, 95% CI 1.7-3.7）, history of spontaneous abortion (aOR 2.7, 95% CI 1.8-4.0), family history of diabetes (aOR 1.6, 95% CI 1.1-2.5), and 3rd degree leucorrhea cleanliness (aOR 1.6，95% CI 1.0-2.7) increased the risk of miscarriage. In men, hepatitis B surface antibody negative (aOR 2.2，95% CI 1.3-3.9), exposure to heavy metals (aOR 3.3，95% CI 1.1-9.7), and interpersonal tension (aOR 2.3，95% CI 1.1-4.5) increased the risk of miscarriage of their wives. Conclusion Couples’ prepregnancy diseases history, contact with harmful substances and other prepregnancy risk factors increase the risk of spontaneous abortion.
